Molnuvir
Molnupiravir is the first-ever investigational oral antiviral therapy for the treatment of SARS-CoV-2 (COVID-19) in non-hospitalized adult patients. It is a potent ribonucleoside analog that blocks SARS-CoV-2 replication by acting as a competitive substrate of virally-encoded RNA-dependent RNA polymerase. The inhibition is what leads to rapid mutations of the virus over multiple viral replication cycles resulting in an antiviral effect.Preliminary findings from a Phase 2a Trial demonstrated that molnupiravir was highly effective at reducing nasopharyngeal SARS-CoV-2 infectious virus and viral RNA, with a favorable safety and tolerability profile.